Yusei is an aspiring turbo duellist from the deprived Satellite area of New Domino City. He's a quiet and level-headed master mechanic who's very good with his hands - so good that he constructed his very own 'D-Wheel', the fastest and most competitive duel runner ever seen! Yusei is a 'Signer', a person chosen to bear the 'Mark of the Dragon' and now carries the Mark of the Crimson Dragon's Head.
JACK ATLAS
The cocky, self-centred Jack is the Riding Duel champion, known by his adoring fans as the 'Master of Faster'. He's viewed Yusei as a bitter rival ever since he lived in the poverty-stricken Satellite area and with his powerful deck and unbelievable ride he's the one who always stands in Yusei's way. Jack is also a Signer and carries the Crimson Dragon's Wings.
REX GOODWIN
Rex Goodwin is the Chief of the Public Security Bureau for New Domino City, but he certainly doesn't live up to his last name - his well-spoken, calm exterior masks a sinister, power-hungry personality deep down. Not only does he know the meaning of the Mark of the Dragon, he hopes to use its power for his own means..
AKIZA IZINSKI
Akiza is a new student at the Academy who has the superhuman ability to inflict physical damage by duelling. Once a cold and distant teenager, she became kind-hearted after meeting Yusei and able to use her power in a positive way, without being afraid of it. Akiza is also a Signer and holds the Black Rose Dragon.
Luna
Luna, known as Ruka or Luca (see below) in the Japanese version, is Leo's fraternal twin sister. She and Leo aid Yusei Fudo, whom they admire and support, in his Duels. Luna is the younger, frail, calmer, more collected of the twins. She is a Signer who possessed the front claw mark. Luna tends to get tired right after a Duel. She has the ability to communicate with Duel Monsters after having spent ample time with Duel Spirits in a different dimension during a coma. Much to her brother Leo's irritation, she tends to candidly point out the various flaws in his plans, but does deeply care for her brother.
Leo
Leo (short for Leonard), known as Rua or Lua in the Japanese version. Luna's twin brother, as well as one of the Signers who possessed the Heart Mark of the Dragon. He and Luna aid Yusei Fudo, whom they admire and support, in his duels. Leo is the older twin of the two and has a lively and blundering personality. In the manga, he is a member of the Skeleton Knight's Army and is one of the duelists currently under the influence of a dark card.